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  • Kumar P, Oster RA, Assimos DG, Ness TJ, and Mitchell T. Bioenergetic profiles of peripheral mononuclear cells and systemic inflammation in women with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). PLOS One. 2024 Feb 15;19(2):e0298981.


  • Kumar P, Laurence E, Crossman DK, Assimos DG, Murphy MP, and Mitchell T. Oxalate disrupts monocyte and macrophage cellular function via Interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling. Redox Biology. 2023 Oct 4:67:102919.



  • Kumar P, Yang Z, Lever J, Chavez M, Fatima H, Crossman D, Maynard C, George J, and Mitchell T. Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat Kidney Stone model. Biochim Biophys Acta Mol Basis Dis. 2022 May 10;1868(9):166442.

  • Laurence E, Kumar P,  and Mitchell T. Novel Translational Approaches To Study Kidney Disease. J Vis Exp. 2022 Aug 30;(186). doi: 10.3791/64711.

  • Gohar E, De Miguel C, Obi I, Daugherty E, Hyndman K, Becker B, Jin C, Sedaka R, Johnston J, Liu P, Speed J, Mitchell T, Kriegel A, Pollock J, and Pollock D. Acclimation to a High Salt Diet is Sex-Dependent. J Am Heart Assoc. 2022 Mar;11(5):e020450.


  • Kumar P, Saini K, Saini V, Mitchell T. Oxalate alters cellular bioenergetics, redox homeostasis, antibacterial response, and immune response in macrophages. Front Immunol. 2021 Oct 21;12:694865.

  • Nam H, Kundu A, Karki S, Brinkley GJ, Chandrashekar DS, Kirkman RL, Liu J, Liberti MV, Locasale JW, Mitchell T, Varambally S, Sudarshan S. TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. JCI Insight, 2021 Oct 5:e148438. 

  • Kumar P, Patel M, Oster RA, Yarlagadda V, Ambrosetti A, Assimos DG, and Mitchell T. Dietary oxalate loading impacts monocyte metabolism and inflammatory signaling in humans. Frontiers in Immunology (Special Research Topic: Immunity and Inflammatory Response in Kidney Stone Disease) 2021 Jan; Accepted.​

  • Kumar P, Bell A, and Mitchell T. Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis. J. Vis. Exp. (Pending Publication), e62192, In-press (2021).


  • Crivelli JJ,  Mitchell T,  Knight J, Wood KD, Assimos DG, Holmes RP, and Fargue S. Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion. Nutrients. 2020 Dec; 13(1):62.​

  • Kumar P, Patel M, Thomas V, Knight J, Holmes RP, and Mitchell T. Dietary oxalate induces urinary nanocrystals in humans. Kidney International Reports. 2020 July; 5(7):1040-1051.​

  • Kundu A, Nam H, Shelar S, Chandrasekhar DS, Brinkley G, Karki S, Mitchell T, Livi CB, Buckhaults P, Kirkman R, Tang Y, Rowe G, Wei S, Varambally S, and Sudarshan S. PRDM16 suppresses HIF-targeted gene expression in kidney cancer. Journal of Experimental Medicine. 2020 Jun 1;217(6).

  • Mitchell T, De Miguel C, and Gohar E. Sex differences in Redox Homeostasis in Renal Disease. Redox Biology. 2020 Mar 9:101489.


  • Mitchell T, Kumar P, Reddy T, Wood KD, Knight J, Assimos DG, and Holmes RP. Dietary Oxalate and Kidney Stone Formation. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F409-F413.


  • Mitchell T. Stay in the Loop: New Insights about Randall's Plaques and Stone Disease. Am J Physiol Renal Physiol. 2018 Sep 19.


  • Patel M, Yarlagadda V, Adedoyin O, Saini V, Assimos DG, Holmes RP, and Mitchell T. Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biology. 2017 Dec; 15:207-215.


  • Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Johnson MS, Wilson L, Barnes S, Landar A, and Darley-Usmar VM. Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils. Redox Biology. 2016 Jun 23;9:57-66

  • Williams J, Holmes RP, Assimos DG, and Mitchell T. Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers. Urology. 2016 Jul;93:224.e1-6

  • Chacko BK, Zhi D, and Mitchell T. The Bioenergetic Health Index is Sensitive to Oxidative Stress in Human Monocytes. Redox Biology. 2016 Aug;8:43-50.


  • Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Barnes S, Arabshahi A, Dell’Italia L, George D, Steele C, George J, Darley-Usmar VM, and Melby S. Hemoglobin-associated Oxidative Stress in the Pericardial Compartment of Post-operative Cardiac Surgery Patients. Lab Invest. 2015 Feb;95(2):132-41.


  • Ravi S§, Mitchell T§, Kramer PA, Chacko BK, and Darley-Usmar VM.  Mitochondria in Monocytes and Macrophages-Implications for Translational and Basic Research.  Int J Biochem Cell Biol. 2014 Aug;53:202-7. §Co-first authors.

  • Chacko BK, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM. The Bioenergetic Health Index: A New Concept in Mitochondrial Translational Research. Clin Sci (Lond). 2014 Sep;127(6):367-73

  • Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, and Darley-Usmar VM. Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets. J Vis Exp. 2014 Mar 27;(85).


  • Mitchell T, Johnson MS,  Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, and Darley-Usmar VM. Dysfunctional autophagy and mitochondrial bioenergetics in a model of Type I diabetes mellitus. Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E585-99.

  • Reily C§, Mitchell T§, Chacko B, Benavides G, Murphy MP, Kalyanaraman B, and Darley-Usmar V. Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biology. 1(1): 86-93 (2013). §Co-first authors.

  • Mitchell T, Chacko B, Ballinger S, Bailey S, Zhang J, and Darley-Usmar V. Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochem Soc Trans. 2013 Feb 1;41(1):127-33.


  • Mitchell T, Chacko B, and Darley-Usmar V. Controlling Radicals in the Powerhouse: Development of MitoSOD. Chem Biol. 2012 Oct 26;19(10):1217-8.

  • Mitchell T, Darley-Usmar V. Metabolic syndrome and mitochondrial dysfunction: insights from pre-clinical studies with a mitochondrially targeted antioxidant. Free Radic Biol Med. 2012 Mar 1;52(5):838-40.


  • Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shirasawa T and MacMillan-Crow LA. Generation and characterization of novel kidney-specific manganese superoxide dismutase knockout mice. Free Radic Biol Med. 2011 Jul 15;51(2):406-16.

  • Mitchell T, Rotaru D, Saba H, Smith RAJ, Murphy MP, and MacMillan-Crow LA. The mitochondria-targeted antioxidant Mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92.

2007- 2010

  • Mitchell T, Saba H, Laakman J, Parajuli N, MacMillan-Crow LA.  Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med. 2010 Nov 1;49(8):1273-82.

  • Munusamy S, Saba H, Mitchell T, Megyesi JK, Brock RW, MacMillan-Crow LA. Alteration of renal respiratory Complex-III during experimental type-1 diabetes. BMC Endocr Disord. 2009 Jan 23;9:2.

  • Saba H, Batinic-Haberle I, Munusamy S, Mitchell T, Lichti C, Megyesi J, and MacMillan-Crow LA. Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radic Biol Med. 2007 May 15;42(10):1571-8.

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